Home Page: Shachi Gosavi

Protein Dynamics, Folding and Function

I currently work with Prof. Jose' Onuchic and Prof. Patricia Jennings on protein folding and dynamics. I am interested in how protein folding and function impact each other. The test bed of all my hypotheses is the β-trefoil fold family.

The following articles have come out of this project:

S. Gosavi, P. C. Whitford, P. A. Jennings and J. N. Onuchic, "Extracting Function from a β-Trefoil Folding Motif", Proc. Natl. Acad. Sci., 105, p. 10384, 2008.
L. L. Chavez, S. Gosavi, P. A. Jennings and J. N. Onuchic, "Multiple routes lead to the native state in the energy landscape of the β-trefoil family", Proc. Natl. Acad. Sci., 103, p. 10254, 2006.
S. Gosavi, L. L. Chavez, P. A. Jennings and J. N. Onuchic, "Topological Frustration and the folding of Interleukin-1β", J. Mol. Biol., 357, p. 986, 2006.

I have worked on the folding dynamics of GFP with Ben Andrews. I hope to continue this project.

B. Andrews, S. Gosavi, J. M. Finke, J. N. Onuchic and P. A. Jennings, "The Multiple Basin Landscape in GFP Folding", Proc. Natl. Acad. Sci., 105, p. 12283, 2008.

I have also worked on Adenylate Kinase with Paul Whitford and helped build an All-Atom Structure Based Model:

P. C. Whitford, J. K. Noel, S. Gosavi, A. Schug, K. Y. Sanbonmatsu and J. N. Onuchic, "An All-atom Structure-Based Potential for Proteins: Bridging Minimal Models with All-atom Empirical Forcefields", PROTEINS: Struct. Funct. Bioinformatics, doi:10.1002/prot.22253.
P. C. Whitford, S. Gosavi, and J. N. Onuchic, "Conformational transitions in adenylate kinase: Allosteric communication reduces misligation", J. Biol. Chem., 283, p. 2042, 2008.